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Depression, the stark reality of sadness and pain that maybe accompanied by suicidal ideation – especially in the very young – needs to be treated. One can feel depressed over anything that doesn’t work out for them in life – failure in exams, the death of a loved one, or separation from someone you are close to. There can be hundreds of reasons, but the experience is similar.

Medical science has traced the root cause of this disorder. Neurons, separated by gaps – synapses – in the brain send and receive messages through neurotransmitters. When the brain is functioning normally, these gaps are clear and chemicals like serotonin and norepinephrine move easily; but when the gaps are not clear, these chemicals get reattached to the parent nerve, creating a chemical imbalance, which leads to depression.

Duloxetine is widely used to treat major depression and anxiety in people. Its’ latest use is in fibromyalgia, which remains a controversy in medical circles because it is not apparent on physical examination, nor can it be corroborated by ‘objective diagnostic’ tests. For the sufferer that won’t mean anything, except that the individual could be complaining of severe fatigue, stiffness in the joints, disturbed sleep, difficulty in swallowing, or a numbness and tingling sensation. But depression, anxiety, or a post-traumatic stress disorder play a key role in fibromyalgia. Some diabetics may experience diabetic neuropathy [nerve damage] – which can also be treated with this medicine.

Those who take Cymbalta must give a list of all medicines they are taking to their psychiatrist, for medicines like narcotics, sleeping pills, muscle relaxers, anti-anxiety or anti-seizure medications all interact with it. Other medicines that may be sold over-the-counter, including those for cold, or allergy, may also increase sleepiness if taken with it. MAO inhibitors, if taken with Cymbalta, can lead to fatal results. The doctor has to know all this, so that the correct dose and medicine regimen can be worked out for you.

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