The reply will differ with every individual medication. Those with a sugar coating should never be crushed, because that coating is to protect the medication from the harsh acid bath found in the belly, allowing the medicine to be released in the gut, not in the stomach. With others, it makes a difference in the rate at which the medication is released. Ask your Pharmacist about that when you pick up the medicine. Many medicines can be crushed and mixed with food such as applesauce, pudding or peanut butter. Others should never, ever be crushed. Your Pharmacist can give you particular instructions for each particular medication. That's what he does for a living.
Yes, why wouldn't it?